Glycophorin-A (GYPA) Antibody (PE / Cyanine 7)
468€ (100 tests)
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935106861
info@markelab.com
name
Glycophorin-A (GYPA) Antibody (PE / Cyanine 7)
category
Primary Antibodies
provider
Abbexa
reference
abx347150
tested applications
FCM
Description
Glycophorin-A (GYPA) Antibody (PE / Cyanine 7) is a mouse monoclonal antibody against Glycophorin-A (GYPA) Antibody (PE / Cyanine 7).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Glycophorin-A (GYPA) |
| Host | Mouse |
| Reactivity | Human, Rat |
| Recommended Dilution | FCM: 4 µl/100 µl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user. The content of a vial (0.4 ml) is sufficient for 100 tests. |
| Clonality | Monoclonal |
| Conjugation | PE / Cyanine 7 |
| Isotype | IgG1 |
| Clone ID | U564 |
| Purification | Purified by size-exclusion chromatography. |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P02724 |
| Gene ID | 2993 |
| Alias | MNS blood group,MN,GPA,MNS,GPSAT,PAS-2,CD235a,MN sialoglycoprotein,Sialoglycoprotein alpha |
| Background | Antibody anti-GYPA |
| Status | RUO |
Descripción
Glycophorin A (GYPA) is a major sialoglycoprotein found on the membrane of human red blood cells (RBCs) and plays a crucial role in the structure and function of the erythrocyte membrane. As a prominent surface protein, it is highly glycosylated and carries sialic acid residues, which contribute to the overall negative charge on the RBC surface, helping to prevent cell aggregation and maintain blood flow. GYPA is most recognized for its involvement in the MNS blood group system, which includes the MN and Ss antigens; variations in the GYPA gene form the molecular basis for these antigenic determinants. This protein is highly relevant in transfusion medicine due to its immunogenic potential and role in blood group antigenicity. In addition to its structural role, GYPA interacts with various pathogens, particularly Plasmodium falciparum, the causative agent of malaria. This interaction is significant for the pathogen’s adhesion to RBCs during infection. GYPA also functions as a receptor for viruses like influenza, playing a broader role in infectious disease dynamics.
