Glycophorin-A (GYPA) Antibody (Biotin)
364€ (0.1 mg)
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935106861
info@markelab.com
name
Glycophorin-A (GYPA) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx347152
tested applications
IHC, FCM
Description
Glycophorin-A (GYPA) Antibody (Biotin) is a mouse monoclonal antibody against Glycophorin-A (GYPA). Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Glycophorin-A (GYPA) |
| Host | Mouse |
| Reactivity | Human, Rat |
| Recommended Dilution | FCM: 1-4 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Biotin |
| Isotype | IgG1 |
| Clone ID | U564 |
| Purification | The purified antibody is conjugated with biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin. |
| Size 1 | 0.1 mg |
| Tested Applications | IHC, FCM |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P02724 |
| Gene ID | 2993 |
| Alias | MNS blood group,MN,GPA,MNS,GPSAT,PAS-2,CD235a,MN sialoglycoprotein,Sialoglycoprotein alpha |
| Background | Antibody anti-GYPA |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Glycophorin A (GYPA) is a major sialoglycoprotein found on the membrane of human red blood cells (RBCs) and plays a crucial role in the structure and function of the erythrocyte membrane. As a prominent surface protein, it is highly glycosylated and carries sialic acid residues, which contribute to the overall negative charge on the RBC surface, helping to prevent cell aggregation and maintain blood flow. GYPA is most recognized for its involvement in the MNS blood group system, which includes the MN and Ss antigens; variations in the GYPA gene form the molecular basis for these antigenic determinants. This protein is highly relevant in transfusion medicine due to its immunogenic potential and role in blood group antigenicity. In addition to its structural role, GYPA interacts with various pathogens, particularly Plasmodium falciparum, the causative agent of malaria. This interaction is significant for the pathogen’s adhesion to RBCs during infection. GYPA also functions as a receptor for viruses like influenza, playing a broader role in infectious disease dynamics.
