Glycine receptor subunit beta (GLRB) Antibody
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Description
Glycine receptor subunit beta (GLRB) Antibody is a Rabbit Polyclonal antibody for the detection of Human GLRB.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Glycine receptor subunit beta (GLRB) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P48167 |
| Background | Antibody anti-GLRB |
| Status | RUO |
Descripción
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Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine(PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1(PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability(PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents(PubMed:25445488).
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