Glycine Receptor Subunit Alpha 1 (GLRA1) Antibody
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Description
Glycine Receptor Subunit Alpha 1 (GLRA1) Antibody is a Rabbit polyclonal antibody for the detection of Human Glycine Receptor Subunit Alpha 1 (GLRA1).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Glycine Receptor Subunit Alpha 1 (GLRA1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P23415 |
| Gene ID | 2741 |
| NCBI Accession | NP_000162.2 |
| Background | Antibody anti-GLRA1 |
| Status | RUO |
Descripción
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Glycine receptors are ligand-gated chloride channels(PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine(PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine(PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization(PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability(PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents(PubMed:25445488). Channel activity is potentiated by ethanol(PubMed:25973519). Potentiation of channel activity by intoxicating levels ot ethanol contribute to the sedative effects of ethanol(By similarity).
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GLRA1 Antibody is a Rabbit Polyclonal antibody against GLRA1. Glycine receptor subunit alpha-1 is a protein that in humans is encoded by the GLRA1 gene. The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Two transcript variants encoding different isoforms have been found for this gene.
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