Glutathione Hydrolase 1 Proenzyme (GGT1) Antibody
416€ (200 µl)
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935106861
info@markelab.com
name
Glutathione Hydrolase 1 Proenzyme (GGT1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432745
tested applications
P-ELISA, WB
Description
GGT1 Antibody is a Goat Polyclonal antibody against GGT1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Glutathione Hydrolase 1 Proenzyme (GGT1) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/128000, WB: 0.1-0.3 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 2678 |
| NCBI Accession | NP_005256.2 |
| Alias | GGT,GTG,GGTD,CD224,GGT 1,D22S672,D22S732 |
| Background | Antibody anti-GGT1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
Gamma-Glutamyltransferase 1 (GGT1) is a membrane-bound enzyme that catalyzes the transfer of gamma-glutamyl moieties from glutathione to amino acids and peptides, playing a critical role in glutathione homeostasis and antioxidant defense GGT1 is essential for the breakdown and recycling of glutathione, a key molecule in detoxifying reactive oxygen species (ROS) and maintaining cellular redox balance GGT1 is highly expressed in the kidney, liver, and other epithelial tissues, where it regulates amino acid transport and cellular responses to oxidative stress Dysregulation of GGT1 activity is associated with oxidative damage, inflammation, and metabolic diseases, including liver disorders, cardiovascular disease, and diabetes Elevated GGT1 levels are also observed in cancers such as hepatocellular carcinoma and lung cancer, where they promote tumor progression and chemoresistance through enhanced glutathione metabolism Additionally, GGT1 serves as a biomarker for liver function and oxidative stress-related conditions Its role in glutathione metabolism and cellular redox regulation underscores its importance in maintaining cellular health and defense mechanisms
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