Glutamate Receptor, Metabotropic 1 (GRM1) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Glutamate Receptor, Metabotropic 1 (GRM1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx213673
tested applications
ELISA, IHC
Description
GRM1 Antibody is a Rabbit Polyclonal against GRM1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Glutamate Receptor, Metabotropic 1 (GRM1) Immunogen: Synthetic peptide of human GRM1. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, IHC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13255 |
| Gene ID | 2911 |
| Alias | GRM1,GPRC1A,MGLU1,MGLUR1 PPP1R85,SCA44,SCAR13,metabotropic glutamate receptor 1,wob,glutamate receptor metabotropic 1 |
| Background | Antibody anti-GRM1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
GRM1, also known as mGluR1, is a G protein-coupled receptor (GPCR) that belongs to the Group I metabotropic glutamate receptors. It is widely expressed in the central nervous system (CNS), particularly in the cerebellum, hippocampus, and cortex, where it regulates excitatory neurotransmission, synaptic plasticity, and intracellular calcium signaling. GRM1 couples to Gq proteins, activating phospholipase C (PLC) and triggering the release of intracellular calcium. It plays a critical role in motor coordination, learning, and memory. Dysregulation of GRM1 has been linked to neurological disorders, including cerebellar ataxia, epilepsy, and neurodegenerative diseases such as Huntington’s disease. In cancer, GRM1 overexpression has been implicated in melanoma progression, where it enhances cell proliferation and survival. GRM1 antagonists are being explored for treating neurological disorders, chronic pain, and cancer, as targeting its signaling pathways can modulate excitatory transmission and cellular growth.
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