Glutamate Metabotropic Receptor 2 (GRM2) Antibody
416€ (200 µl)
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935106861
info@markelab.com
name
Glutamate Metabotropic Receptor 2 (GRM2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431034
tested applications
P-ELISA, WB, IHC
Description
GRM2 Antibody is a Goat Polyclonal antibody against GRM2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Glutamate Metabotropic Receptor 2 (GRM2) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/16000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 2912, 108068, 24415 |
| NCBI Accession | NP_000830.2, NP_001123535.1 |
| Alias | GRM2,GLUR2,GPRC1B,MGLUR2,mGlu2,metabotropic glutamate receptor 2 |
| Background | Antibody anti-GRM2 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
GRM2, or mGluR2, is a Group II metabotropic glutamate receptor primarily expressed in the central nervous system, including the hippocampus, prefrontal cortex, and thalamus. GRM2 couples to Gi/o proteins, inhibiting adenylate cyclase activity and reducing cyclic AMP (cAMP) levels, leading to decreased glutamate release and dampened excitatory signaling. GRM2 functions as an autoreceptor or heteroreceptor, modulating synaptic plasticity and neuronal excitability. It plays a significant role in cognitive function, emotional regulation, and stress responses. Dysregulation of GRM2 has been associated with psychiatric disorders such as anxiety, schizophrenia, and depression, where altered glutamate signaling disrupts synaptic balance. GRM2 agonists have shown promise as therapeutic agents for mood and anxiety disorders, as they reduce excessive glutamate release and normalize neuronal signaling. GRM2 is also being investigated for its role in addiction and neurodegeneration, making it a key target for psychiatric and neurological therapies.
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