Gastrin/Cholecystokinin Type B Receptor (CCKBR) Antibody (Biotin)
169€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Gastrin/Cholecystokinin Type B Receptor (CCKBR) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx335789
tested applications
ELISA
Description
CCKBR Antibody (Biotin) is a Rabbit Polyclonal against CCKBR.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Gastrin/Cholecystokinin Type B Receptor (CCKBR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P32239 |
| Gene ID | 887 |
| Alias | CCKBR,CCK2 receptor,CK-B receptor,cholecystokinin-2 receptor ,CHOLREC,gastrin/cholecystokinin type B receptor,CCK-B/gastrin receptor,CCK-2R,CCK-B,CCK2R,GASR |
| Background | Antibody anti-CCKBR |
| Status | RUO |
Descripción
CCKBR, also known as CCK2R, is a G protein-coupled receptor (GPCR) that binds both gastrin and cholecystokinin (CCK) peptides, playing critical roles in gastrointestinal function and brain signaling. It is expressed in the stomach, pancreas, brain, and certain tumors. In the gastrointestinal system, CCKBR regulates gastric acid secretion by stimulating parietal cells and promotes gastric mucosal growth, supporting digestive processes. In the central nervous system, CCKBR is involved in modulating anxiety, pain, and satiety through interactions with neurotransmitter systems. Its activation triggers pathways like phospholipase C (PLC), calcium mobilization, and MAPK signaling, leading to cellular proliferation, enzyme secretion, and neuronal modulation. CCKBR is highly implicated in gastric and pancreatic cancers, where gastrin-mediated activation enhances cell proliferation, survival, and tumor progression. Overexpression of CCKBR has been observed in gastric adenocarcinomas, making it a potential therapeutic target. Additionally, dysregulation of CCKBR signaling contributes to gastrointestinal disorders, including peptic ulcers and Zollinger-Ellison syndrome, characterized by excessive gastrin production. CCKBR is also being explored in neuropsychiatric research for its roles in anxiety and pain modulation. Overall, CCKBR regulates digestive and neuronal processes but contributes to disease progression when overexpressed or dysregulated.
Related Products
Human CCKBR(Gastrin/cholecystokinin type B receptor) ELISA Kit
Ver Producto
anti- CCKBR-specific antibody
Ver Producto
Gastrin/Cholecystokinin Type B Receptor (CCKBR) Antibody
CCKBR Antibody is a Rabbit Polyclonal Antibody against CCKBR.
Ver Producto