Gastric Inhibitory Polypeptide (GIP) Antibody

Este producto es parte de GIP - Gastric inhibitory polypeptide ( Receptor)
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273€ (100 µl)

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935106861
info@markelab.com
name
Gastric Inhibitory Polypeptide (GIP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130323
tested applications
WB, IHC, IF/ICC

Description

Gastric Inhibitory Polypeptide Antibody is a Rabbit Polyclonal against Gastric Inhibitory Polypeptide.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Gastric Inhibitory Polypeptide (GIP)
Host
Rabbit
Reactivity
Rat
Recommended Dilution
WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Purification
Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
Size 1
100 µl
Size 2
200 µl
Size 3
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability
Shipped within 5-7 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q06145
Alias
Glucose-dependent insulinotropic polypeptide,Incretin
Background
Antibody anti-GIP
Status
RUO

Descripción

GIP, also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid hormone secreted by K-cells in the duodenum and jejunum in response to nutrient ingestion, particularly glucose, fats, and amino acids GIP acts as a critical incretin hormone that enhances glucose-dependent insulin secretion from pancreatic β-cells by activating cAMP-dependent pathways and protein kinase A signaling GIP also regulates lipid metabolism by stimulating lipoprotein lipase activity in adipose tissue, promoting triglyceride uptake and energy storage GIP further supports bone homeostasis by enhancing osteoblast function, contributing to bone formation and mineralization Dysregulation of GIP levels and signaling is associated with insulin resistance, obesity, and type 2 diabetes where its insulinotropic effects are impaired despite elevated circulating levels GIP-based therapies, including dual GIP/GLP-1 receptor agonists, have shown therapeutic potential in improving glycemic control and promoting weight loss in metabolic disorders

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