Gamma-Glutamyl Hydrolase (GGH) Antibody (FITC)
169€ (20 µg)
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Name
Gamma-Glutamyl Hydrolase (GGH) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx316897
Description
GGH Antibody (FITC) is a Rabbit Polyclonal against GGH conjugated to FITC.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Gamma-Glutamyl Hydrolase (GGH) Immunogen: Recombinant Human Gamma-glutamyl hydrolase protein (219-293AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92820 |
| Gene ID | 8836 |
| OMIM | 601509 |
| Alias | GATD10,GH,Gamma-Glu-X carboxypeptidase |
| Background | Antibody anti-GGH |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Gamma-Glutamyl Hydrolase (GGH) is an enzyme involved in folate metabolism that catalyzes the hydrolysis of polyglutamated folates into monoglutamates, which are required for folate transport and cellular uptake GGH plays a key role in regulating intracellular folate levels, which are critical for DNA synthesis, repair, and methylation processes Dysregulation of GGH activity can affect cellular proliferation and is associated with conditions such as cancer, where altered folate metabolism promotes tumor growth and progression GGH expression has been linked to resistance to antifolate chemotherapeutic agents like methotrexate, as increased GGH activity reduces the retention of polyglutamated drugs, decreasing their efficacy GGH also participates in redox regulation, as folate metabolism contributes to cellular antioxidant defense pathways Studies highlight its involvement in conditions like neural tube defects and anemia due to its critical role in folate homeostasis Emerging evidence suggests that GGH activity may serve as a biomarker for cancer therapy response and other folate-related metabolic disorders
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