Galanin Receptor Type 1 (GALR1) Antibody

Este producto es parte de GALR- Galanin Receptor
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416€ (200 µl)

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935106861
info@markelab.com
name
Galanin Receptor Type 1 (GALR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431277
tested applications
P-ELISA, WB

Description

GALR1 Antibody is a Goat Polyclonal antibody against GALR1.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Galanin Receptor Type 1 (GALR1)
Host
Goat
Reactivity
Rat
Recommended Dilution
P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Size 1
200 µl
Form
Liquid
Tested Applications
P-ELISA, WB
Buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P47211
Gene ID
2587
NCBI Accession
NP_001471.2
Alias
GALR1,GALNR,GALNR1,GAL1 receptor
Background
Antibody anti-GALR1
Status
RUO
Note
Concentration: 0.5 mg/ml -

Descripción

GALR1 is a G protein-coupled receptor (GPCR) that binds the neuropeptide galanin, mediating inhibitory signaling through coupling to Gi/o proteins. This interaction reduces intracellular cyclic AMP (cAMP) levels and modulates potassium and calcium channels, resulting in neuronal hyperpolarization and inhibition of neurotransmitter release. GALR1 is widely expressed in the central nervous system (CNS), including the hippocampus, hypothalamus, and spinal cord, where it regulates processes like pain modulation, mood regulation, and feeding behavior. In pain pathways, GALR1 activation suppresses nociceptive transmission, providing antinociceptive effects. GALR1 also exhibits neuroprotective properties in neurodegenerative disorders, such as Alzheimer’s disease, by reducing excitotoxicity. In cancer, GALR1 acts as a tumor suppressor, particularly in head and neck squamous cell carcinoma, where its activation inhibits cell proliferation and induces apoptosis. Dysregulation of GALR1 signaling is associated with mood disorders, including depression and anxiety, where impaired inhibitory signaling contributes to emotional imbalance. Its role in pain modulation, neuroprotection, and tumor suppression positions GALR1 as a promising therapeutic target for neurological disorders, pain management, and cancer therapy.

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