GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) Antibody (HRP)

Este producto es parte de GABARAPL - GABA A Receptor Associated Protein Like Protein
GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) Antibody (HRP)

Pida mas información

935106861

info@markelab.com

Precio

169€ (20 µg)

Antibody anti-GABARAPL2

proveedor

Abbexa

reference

abx108277

Tested Applications

ELISA

reactivity

Human, Rat

status

RUO

clonality

Polyclonal

Descripción

Gamma-aminobutyric acid receptor-associated protein-like 2 Antibody (HRP) is a Rabbit Polyclonal antibody against Gamma-aminobutyric acid receptor-associated protein-like 2 conjugated to HRP.


Background

GABARAPL2, another member of the GABARAP family, is essential for receptor trafficking, intracellular transport, and autophagy regulation. Like GABARAPL1, GABARAPL2 interacts with GABA-A receptors to facilitate their trafficking and proper membrane localization, maintaining synaptic inhibitory neurotransmission. It is also a core component of the autophagy machinery, functioning in autophagosome formation and lysosomal delivery of cargo proteins. GABARAPL2 interacts with autophagy-related proteins like LC3 and ATG8 to mediate selective autophagy processes, including the degradation of misfolded proteins and damaged organelles. Dysregulation of GABARAPL2 is associated with neurodegenerative disorders, such as Huntington’s and ALS, where defective autophagy contributes to protein aggregation and neuronal loss. In cancer, GABARAPL2 plays a dual role, promoting survival or apoptosis depending on cellular context, highlighting its involvement in tumor growth and chemoresistance. Its role in maintaining cellular homeostasis through autophagy and receptor regulation makes GABARAPL2 a promising therapeutic target for neurodegenerative diseases and cancer.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Rat


immunogen target

GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2)


host

Rabbit


isotype

IgG


conjugation

HRP


form

Liquid


tested applications

ELISA


purity

> 95%


purification

Purified by Protein G.


recommended dilution

Optimal dilutions/concentrations should be determined by the end user.


buffer

0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.


size 1

20 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

1 mg


storage

Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.


or code

GABARAPL2


dry ice

No


availability

Shipped within 5-10 working days.


alias

ATG8,ATG8C,GATE-16,GATE16,GEF-2,GEF2


note

Concentration: 0.33 mg/ml -


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