GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) Antibody
286€ (100 µl)
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Name
GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx128282
Tested Applications
IHC
Description
GABARAPL2 Antibody is a Rabbit Polyclonal against GABARAPL2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) Immunogen: GABARAPL2 (Met1-Phe117) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB (Predicted): 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P60520 |
| Alias | ATG8,ATG8C,GATE-16,GATE16,GEF-2,GEF2 |
| Background | Antibody anti-GABARAPL2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
GABARAPL2, another member of the GABARAP family, is essential for receptor trafficking, intracellular transport, and autophagy regulation. Like GABARAPL1, GABARAPL2 interacts with GABA-A receptors to facilitate their trafficking and proper membrane localization, maintaining synaptic inhibitory neurotransmission. It is also a core component of the autophagy machinery, functioning in autophagosome formation and lysosomal delivery of cargo proteins. GABARAPL2 interacts with autophagy-related proteins like LC3 and ATG8 to mediate selective autophagy processes, including the degradation of misfolded proteins and damaged organelles. Dysregulation of GABARAPL2 is associated with neurodegenerative disorders, such as Huntington’s and ALS, where defective autophagy contributes to protein aggregation and neuronal loss. In cancer, GABARAPL2 plays a dual role, promoting survival or apoptosis depending on cellular context, highlighting its involvement in tumor growth and chemoresistance. Its role in maintaining cellular homeostasis through autophagy and receptor regulation makes GABARAPL2 a promising therapeutic target for neurodegenerative diseases and cancer.
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