3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase FUT3 (FUT3) Antibody (Biotin)
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Description
FUT3 Antibody (Biotin) is a Rabbit Polyclonal against FUT3.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase FUT3 (FUT3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21217 |
| Gene ID | 2525 |
| OMIM | 111100 |
| Alias | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3,Lewis blood group,LE,Les,FT3B,CD174,FucT-III,Fucosyltransferase III |
| Background | Antibody anti-FUT3 |
| Status | RUO |
Descripción
Fucosyltransferase 3 (FUT3) is an enzyme within the glycosyltransferase family that is essential for the biosynthesis of specific carbohydrate structures on glycoproteins and glycolipids. FUT3 is responsible for catalyzing the addition of fucose, a hexose sugar, to various glycan substrates through α(1,3)- and α(1,4)-linkages, which are critical for the synthesis of the Lewis antigen family, including Lewis a (Le^a) and Lewis b (Le^b) antigens. These carbohydrate structures are integral components of cell surface glycoconjugates and play essential roles in cell-cell adhesion, recognition, and signaling. Encoded by the FUT3 gene located on chromosome 19p13.3, FUT3 is primarily expressed in epithelial tissues and leukocytes, especially in the gastrointestinal tract and other mucosal tissues. It is one of several fucosyltransferases in the human genome, with FUT3 being the most involved in the generation of Lewis antigens. The genetic variations in FUT3 are known to result in different phenotypes of Lewis antigens, which are important in blood group determination and are relevant to various diseases, including cancers and inflammatory conditions.
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