Frizzled Homolog 9 (FZD9) Antibody
221€ (50 µg)
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935106861
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name
Frizzled Homolog 9 (FZD9) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx326872
tested applications
ELISA, IHC
Description
FZD9 Antibody is a Rabbit Polyclonal against FZD9.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Frizzled Homolog 9 (FZD9) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/10000 - 1/20000, IHC: 1/50 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00144 |
| Gene ID | 8326 |
| Alias | FZD9,FZD3,CD349,frizzled family receptor 9 |
| Background | Antibody anti-FZD9 |
| Status | RUO |
Descripción
FZD9 is a member of the Frizzled family of G protein-coupled receptors involved in Wnt signaling, primarily through the canonical β-catenin-dependent pathway. It is highly expressed in the brain, spleen, and bone, where it plays critical roles in neuronal development, immune regulation, and bone homeostasis. In bone biology, FZD9 promotes osteoblast differentiation and mineralization, contributing to skeletal development and bone repair. Deletion or reduced expression of FZD9 is associated with bone fragility and osteoporosis, highlighting its importance in bone formation. In the central nervous system, FZD9 regulates neural connectivity, synaptic plasticity, and cognitive function, with its dysregulation linked to neurodevelopmental disorders and neurodegenerative diseases like Alzheimer’s. FZD9 also contributes to immune system function, particularly in lymphocyte development and maturation. In cancer, FZD9 expression is altered in B-cell malignancies, such as multiple myeloma, where it influences cell proliferation and survival through Wnt signaling activation. FZD9’s role in maintaining tissue homeostasis and its dysregulation in bone disease and cancer make it a potential therapeutic target for osteoporosis and hematological malignancies.
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