Frizzled Homolog 8 (FZD8) Antibody
416€ (200 µl)
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name
Frizzled Homolog 8 (FZD8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430074
tested applications
P-ELISA, WB, IHC, IF/ICC
Description
FZD8 Antibody is a Goat Polyclonal antibody against FZD8.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Frizzled Homolog 8 (FZD8) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC, IF/ICC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 8325, 14370 |
| NCBI Accession | NP_114072.1 |
| Alias | FZD8,FZ-8,hFZ8,frizzled family receptor 8,Fz8 |
| Background | Antibody anti-FZD8 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
FZD8 is a member of the Frizzled receptor family that mediates Wnt signaling, predominantly through the canonical β-catenin-dependent pathway. It is expressed in various tissues, including the brain, heart, and bone, where it regulates cell proliferation, differentiation, and tissue homeostasis. FZD8 plays a significant role in bone formation and osteoblast differentiation, making it essential for skeletal development and regeneration. In cancer, FZD8 is overexpressed in lung, breast, and prostate cancers, where it promotes cell proliferation, survival, and therapy resistance through enhanced Wnt/β-catenin signaling. FZD8 also contributes to angiogenesis and metastasis by regulating endothelial cell function and tumor vascularization. Its role in brain development includes regulating neural differentiation and synaptic plasticity. FZD8 activation triggers downstream pathways like PI3K/Akt and MAPK, driving cellular responses critical for growth and repair. Dysregulation of FZD8 is associated with developmental defects, cancer progression, and bone disorders. Therapeutic targeting of FZD8 to modulate Wnt signaling is being explored to treat cancers and bone-related diseases, highlighting its importance in development and disease.
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