Frizzled Homolog 4 (FZD4) Antibody
260€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Frizzled Homolog 4 (FZD4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx214268
tested applications
ELISA, WB
Description
FZD4 Antibody is a Rabbit Polyclonal against FZD4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Frizzled Homolog 4 (FZD4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, WB: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9ULV1 |
| Gene ID | 8322 |
| Alias | FZD4,Fz4,EVR1,FEVR,Fz-4,FzE4,GPC, hFz4,CD344,FZD4S,frizzled receptor 4 |
| Background | Antibody anti-FZD4 |
| Status | RUO |
Descripción
FZD4 is a Wnt receptor that mediates canonical β-catenin-dependent signaling and non-canonical pathways. It is expressed in vascular endothelial cells, the retina, and skeletal tissue, playing a key role in angiogenesis, vascular integrity, and retinal development. FZD4 interacts with Wnt ligands and coreceptors like LRP5/6 to activate β-catenin signaling, which is essential for retinal vascularization and blood-retina barrier maintenance. Mutations in FZD4 are associated with familial exudative vitreoretinopathy (FEVR), a genetic disorder characterized by incomplete retinal vascular development, leading to vision loss. In cancer, FZD4 promotes tumor angiogenesis and metastasis by activating Wnt signaling pathways that support endothelial cell proliferation and survival. Its overexpression has been observed in breast and colorectal cancers, where it enhances angiogenesis and therapy resistance. FZD4 also regulates bone formation and osteoblast differentiation, contributing to skeletal development. Targeting FZD4 and its signaling pathways has therapeutic potential in vascular disorders, cancer, and ocular diseases. Overall, FZD4 is essential for vascular development and maintenance, with dysregulation contributing to angiogenic disorders and tumor progression.
Related Products
Human FZD4 (Frizzled-4) ELISA Kit
Ver Producto
FZD4 antibody
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.
Ver Producto
Frizzled Homolog 4 (FZD4) Antibody
FZD4 Antibody is a Rabbit Polyclonal Antibody against FZD4.
Ver Producto