Formyl Peptide Receptor 2 (FPR2) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Formyl Peptide Receptor 2 (FPR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx339085
tested applications
ELISA, IHC
Description
FPR2 Antibody is a Rabbit Polyclonal against FPR2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Formyl Peptide Receptor 2 (FPR2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/1000 - 1/10000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P25090 |
| Gene ID | 2358 |
| Alias | FPR2,ALXR,FMLPX,FPRH1,LXA4R,ALX,FPRH2,FPRL1,RFP,formyl peptide receptor-like 1,HM63,FMLP-R-II |
| Background | Antibody anti-FPR2 |
| Status | RUO |
Descripción
FPR2, also known as ALX/FPR2, is a G protein-coupled receptor with dual roles in pro- and anti-inflammatory signaling. It is expressed on neutrophils, macrophages, and epithelial cells, where it recognizes formylated peptides, lipoxin A4, and other endogenous or pathogen-derived ligands. FPR2 signaling activates pathways like PI3K/Akt and MAPK, regulating immune cell chemotaxis, phagocytosis, and cytokine production. Uniquely, FPR2 mediates both inflammatory responses and resolution of inflammation, depending on the ligand. For example, it promotes inflammation in response to bacterial peptides but facilitates resolution through lipoxin A4, which reduces neutrophil recruitment and promotes tissue repair. Dysregulation of FPR2 is linked to chronic inflammation, autoimmune diseases, and sepsis. In cancer, FPR2 can either support or inhibit tumor progression by influencing immune cell behavior and tumor microenvironment composition. FPR2’s ability to switch between pro- and anti-inflammatory states highlights its therapeutic potential for modulating inflammation, resolving chronic inflammatory diseases, and targeting immune dysfunction in cancer.
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