Formyl Peptide Receptor 1 (FPR1) Antibody
221€ (50 µg)
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name
Formyl Peptide Receptor 1 (FPR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx324943
tested applications
ELISA, WB, IHC, IF/ICC
Description
FPR1 Antibody is a Rabbit Polyclonal against FPR1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Formyl Peptide Receptor 1 (FPR1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/5000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21462 |
| Gene ID | 2357 |
| Alias | FPR1,NFPR,FPR,formyl peptide receptor 1,fMLF-R,FPR,FMLP |
| Background | Antibody anti-FPR1 |
| Status | RUO |
Descripción
FPR1 is a G protein-coupled receptor (GPCR) expressed predominantly on immune cells, such as neutrophils and macrophages, where it mediates chemotaxis and host defense responses. It recognizes formylated peptides derived from bacterial and mitochondrial proteins, triggering immune cell recruitment to infection or damaged tissues. FPR1 activation stimulates downstream signaling pathways, including PI3K/Akt, MAPK, and calcium mobilization, leading to cellular migration, degranulation, and reactive oxygen species (ROS) production. It plays a critical role in the innate immune system by detecting bacterial infections and sterile inflammation. Dysregulation of FPR1 signaling contributes to chronic inflammatory diseases, autoimmune disorders, and impaired immune responses. In cancer, FPR1 expression has been associated with tumor progression and metastasis, where it can enhance cell migration and immune evasion. FPR1 also influences tissue repair and wound healing by directing immune cells to sites of injury. Its role in immune surveillance, inflammation, and cancer progression makes it an important target for therapies aimed at modulating immune responses and improving host defense mechanisms.
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