Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody (HRP)

Este producto es parte de FGFRL1 - fibroblast growth factor receptor like 1
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169€ (20 µg)

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935106861
info@markelab.com
name
Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx335700
tested applications
ELISA

Description

FGFRL1 Antibody (HRP) is a Rabbit Polyclonal against FGFRL1.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
HRP
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q8N441
Gene ID
53834
Alias
FHFR,FGFR5,FGFR-5,Fibroblast growth factor receptor 5,FGFR-like protein,FGF homologous factor receptor,FGF receptor-like protein 1
Background
Antibody anti-FGFRL1
Status
RUO

Descripción

Fibroblast growth factor receptor like 1 (FGFRL1) FGFRL1 is a unique member of the FGFR family that lacks the intracellular tyrosine kinase domain, distinguishing it from other FGFRs. FGFRL1 contains an extracellular ligand-binding domain similar to other FGFRs, capable of binding FGFs and interacting with heparan sulfate proteoglycans. However, instead of activating intracellular signaling cascades, FGFRL1 is thought to act as a decoy receptor, modulating FGF availability and signaling. FGFRL1 plays a role in skeletal development, cartilage formation, and kidney morphogenesis, as evidenced by its high expression in these tissues during development. Mutations or dysregulation of FGFRL1 have been linked to skeletal abnormalities, including craniosynostosis and cartilage defects. Additionally, FGFRL1 may influence cellular adhesion and migration through interactions with extracellular matrix components. Its distinctive lack of kinase activity highlights its role as a regulatory rather than a signaling receptor in FGF-mediated processes.

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