Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody
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Description
Polyclonal Antibody to Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8N441 |
| Alias | FHFR,FGFR5,FGFR-5,Fibroblast growth factor receptor 5,FGFR-like protein,FGF homologous factor receptor,FGF receptor-like protein 1 |
| Background | Antibody anti-FGFRL1 |
| Status | RUO |
Descripción
Fibroblast growth factor receptor like 1 (FGFRL1) FGFRL1 is a unique member of the FGFR family that lacks the intracellular tyrosine kinase domain, distinguishing it from other FGFRs. FGFRL1 contains an extracellular ligand-binding domain similar to other FGFRs, capable of binding FGFs and interacting with heparan sulfate proteoglycans. However, instead of activating intracellular signaling cascades, FGFRL1 is thought to act as a decoy receptor, modulating FGF availability and signaling. FGFRL1 plays a role in skeletal development, cartilage formation, and kidney morphogenesis, as evidenced by its high expression in these tissues during development. Mutations or dysregulation of FGFRL1 have been linked to skeletal abnormalities, including craniosynostosis and cartilage defects. Additionally, FGFRL1 may influence cellular adhesion and migration through interactions with extracellular matrix components. Its distinctive lack of kinase activity highlights its role as a regulatory rather than a signaling receptor in FGF-mediated processes.
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