Fibroblast Growth Factor Receptor 1 (FGFR1) Antibody (FITC)
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935106861
info@markelab.com
Precio
162.5€ (20 µg)
Antibody anti-FGFR1
proveedor
Abbexareference
abx314827Tested Applications
reactivity
Humanstatus
RUOclonality
PolyclonalDescripción
FGFR1 Antibody (FITC) is a Rabbit Polyclonal against FGFR1 conjugated to FITC.
Background
Fibroblast growth factor receptor 1 (FGFR1) FGFR1 is a transmembrane tyrosine kinase receptor that binds fibroblast growth factors (FGFs), playing a critical role in cellular proliferation, differentiation, and survival. FGFR1 consists of an extracellular ligand-binding domain composed of three immunoglobulin-like loops, a single transmembrane helix, and an intracellular tyrosine kinase domain. Upon FGF binding, FGFR1 undergoes dimerization and autophosphorylation, triggering downstream signaling pathways such as the MAPK, PI3K-AKT, and PLCγ pathways. FGFR1 is essential in embryonic development, angiogenesis, and tissue repair, and its dysregulation is implicated in various cancers, including lung and breast cancer, where aberrant FGFR1 activation promotes tumor growth and survival. FGFR1 is also involved in skeletal development, and mutations in the FGFR1 gene can lead to developmental disorders such as Pfeiffer syndrome. Its widespread expression in multiple tissues highlights its diverse biological roles.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Fibroblast Growth Factor Receptor 1 (FGFR1)
host
Rabbit
conjugation
FITC
form
Liquid
purity
> 95%
purification
Purified by Protein G.
buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
size 1
20 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
1 mg
storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
or code
FGFR1
dry ice
No
availability
Shipped within 5-10 working days.
alias
H2,H3,H4,5,CEK,FLG,BFGFR,N-SAN,CD331,FGFR-1,Proto-oncogene c-Fgr,Fms-like tyrosine kinase 2,Pfeiffer syndrome
uniprot id
NCBI accession
NM_023110.2
note
This product is for research use only.
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