Fibroblast Growth Factor 23 (FGF23) Antibody

Este producto es parte de FGF23 - Fibroblast Growth Factor 23
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364€ (100 µg)

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935106861
info@markelab.com
name
Fibroblast Growth Factor 23 (FGF23) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx215366
tested applications
ELISA, WB

Description

Fibroblast Growth Factor 23 (FGF23) Antibody is a Rabbit Polyclonal antibody for the detection of FGF23.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Fibroblast Growth Factor 23 (FGF23)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
≥ 95% (SDS-PAGE)
Purification
Purified by immunogen affinity chromatography.
Size 1
100 µg
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9GZV9
Gene ID
8074
NCBI Accession
NP_065689.1
OMIM
193100
Alias
ADHR,FGFN,HYPF,HFTC2,HPDR2,PHPTC,Phosphatonin,Tumor-derived hypophosphatemia-inducing factor
Background
Antibody anti-FGF23
Status
RUO
Note
Concentration: 2 mg/ml - Validity: 12 months.

Descripción

FGF23 is a phosphaturic hormone primarily secreted by osteocytes and osteoblasts in bone tissue. It regulates phosphate homeostasis and vitamin D metabolism by reducing phosphate reabsorption in the kidneys and suppressing the synthesis of 1,25-dihydroxyvitamin D. FGF23 binds to its receptor in the presence of α-Klotho, promoting phosphate excretion to maintain serum phosphate levels. Elevated FGF23 levels are associated with chronic kidney disease (CKD), where impaired renal function leads to hyperphosphatemia and secondary hyperparathyroidism. Mutations in FGF23 can cause disorders like hypophosphatemic rickets and osteomalacia, characterized by bone mineralization defects. FGF23’s role in phosphate balance and bone health makes it a key target for managing CKD and related mineral metabolism disorders.

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