FGFR4 Antibody
429€ (100 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
FGFR4 Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx140464
Tested Applications
FCM
Description
FGFR4 Antibody is a Mouse Monoclonal against FGFR4.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: FGFR4 Immunogen: NIH 3T3 cells transfected with full length Human CD334. |
| Host | Mouse |
| Reactivity | Human |
| Detection Method | Laser Line: 550 Excitation/Emission: 565/575 |
| Recommended Dilution | FCM: 10 µl/100 µl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | PE |
| Isotype | IgG1 Kappa |
| Clone ID | M282 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P22455 |
| Gene ID | 2264 |
| Alias | TKF,JTK2,CD334,FGFR-4 |
| Background | Antibody anti-FGFR4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Fibroblast growth factor receptor 4 (FGFR4) FGFR4 is a member of the fibroblast growth factor receptor (FGFR) family, characterized as a transmembrane tyrosine kinase receptor that binds FGFs to regulate cell proliferation, differentiation, migration, and survival. Structurally, FGFR4 consists of an extracellular ligand-binding domain composed of three immunoglobulin-like loops, a single transmembrane domain, and an intracellular tyrosine kinase domain. FGFR4 plays essential roles in embryonic development, metabolism, and tissue homeostasis, particularly in liver, muscle, and endocrine tissues. Ligand binding activates downstream signaling cascades, including the MAPK, PI3K-AKT, and STAT pathways, which are critical for cell growth and survival. Dysregulation of FGFR4 signaling has been implicated in various cancers, such as hepatocellular carcinoma and rhabdomyosarcoma, where overexpression or mutation drives tumor growth and metastasis. Its selective expression in specific tissues and its involvement in metabolic regulation, including bile acid synthesis, highlight its specialized biological functions and potential as a therapeutic target in oncology and metabolic disorders.
Productos relacionados
Fibroblast Growth Factor Receptor 4 (FGFR4) Antibody
FGFR4 Antibody is a Rabbit Polyclonal Antibody against FGFR4.…
Ver producto
Fibroblast Growth Factor Receptor 4 (FGFR4) Antibody
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence …
Ver producto
FGFR4 (Phospho-Tyr642) Antibody
Rabbit polyclonal antibody against FGFR4 protein. Immunogen region is C-terminal. Specificity is as follows for the reac…
Ver producto