FGFR1 (Phospho-Tyr766) Antibody
52€ (10 µg)
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Name
FGFR1 (Phospho-Tyr766) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx012438
Tested Applications
ELISA, WB, IHC
Description
Rabbit polyclonal antibody against FGFR1 protein. Immunogen region is C-terminal. Specificity is as follows for the reactive species: H:Y766, M:Y766, R:Y673.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: FGFR1 Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human FGFR1 around the phosphorylation site of tyrosine 766 (Q-E-YP-L-D). |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P11362 |
| Alias | H2,H3,H4,5,CEK,FLG,BFGFR,N-SAN,CD331,FGFR-1,Proto-oncogene c-Fgr,Fms-like tyrosine kinase 2,Pfeiffer syndrome |
| Background | Antibody anti-FGFR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Fibroblast growth factor receptor 1 (FGFR1) FGFR1 is a transmembrane tyrosine kinase receptor that binds fibroblast growth factors (FGFs), playing a critical role in cellular proliferation, differentiation, and survival. FGFR1 consists of an extracellular ligand-binding domain composed of three immunoglobulin-like loops, a single transmembrane helix, and an intracellular tyrosine kinase domain. Upon FGF binding, FGFR1 undergoes dimerization and autophosphorylation, triggering downstream signaling pathways such as the MAPK, PI3K-AKT, and PLCγ pathways. FGFR1 is essential in embryonic development, angiogenesis, and tissue repair, and its dysregulation is implicated in various cancers, including lung and breast cancer, where aberrant FGFR1 activation promotes tumor growth and survival. FGFR1 is also involved in skeletal development, and mutations in the FGFR1 gene can lead to developmental disorders such as Pfeiffer syndrome. Its widespread expression in multiple tissues highlights its diverse biological roles.
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