Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B (FCGR2B) Antibody
416€ (200 µl)
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935106861
info@markelab.com
name
Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B (FCGR2B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430204
tested applications
P-ELISA, WB, IHC, IF/ICC, FCM
Description
FCGR2B Antibody is a Goat Polyclonal antibody against FCGR2B.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/32000, WB: 0.3-1 µg/ml, IHC: 6-8 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC, IF/ICC, FCM |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 2213 |
| NCBI Accession | NP_003992.3, NP_001002273.1, NP_001002274.1, NP_001002275.1, NP_001177757.1 |
| Alias | CD32,FCG2,CD32B,FCGR2,IGFR2,FCGR2C,FcGRIIB,FcRII-c,FcgammaRIIb,Low affinity immunoglobulin gamma Fc region receptor II-b,IgG Fc receptor II-b,CDw32,Fc-gamma RII-b |
| Background | Antibody anti-FCGR2B |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
FCGR2B (Fc gamma receptor IIB), also known as CD32B, is a low-affinity receptor for the Fc portion of IgG antibodies, primarily responsible for regulating immune responses by mediating inhibitory signaling. It plays a crucial role in the balance between activation and inhibition of immune cells, preventing excessive inflammation and autoimmunity. Unlike its closely related receptor, FCGR2A, which triggers activating signals, FCGR2B is the only inhibitory receptor within the Fc gamma receptor family. This receptor is predominantly expressed on B cells, dendritic cells, macrophages, and other immune cells. FCGR2B is part of the larger family of Fc gamma receptors (FcγRs), which bind the Fc region of immunoglobulin G (IgG) to mediate immune responses such as phagocytosis, cytokine release, and the clearance of immune complexes. Its inhibitory role is vital in the prevention of autoimmune reactions and the modulation of inflammatory responses.
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