Fc Fragment of IgG, Low Affinity IIa, Receptor / CD32 (FCGR2A) Antibody (FITC)
169€ (20 µg)
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935106861
info@markelab.com
name
Fc Fragment of IgG, Low Affinity IIa, Receptor / CD32 (FCGR2A) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx314399
Description
FCGR2A Antibody (FITC) is a Rabbit Polyclonal against FCGR2A conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Fc Fragment of IgG, Low Affinity IIa, Receptor / CD32 (FCGR2A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P12318 |
| Gene ID | 2212 |
| NCBI Accession | NP_001129691.1, NM_001136219.1 |
| OMIM | 146790 |
| Alias | CD32,FCG2,FcGR,CD32A,CDw32,FCGR2,IGFR2,FCGR2A,FcgammaRIIa,Low affinity immunoglobulin gamma Fc region receptor II-a,IgG Fc receptor II-a,Fc-gamma RII-a |
| Background | Antibody anti-FCGR2A |
| Status | RUO |
Descripción
FCGR2A (Fc gamma receptor IIa), also known as CD32a, is a low-affinity receptor for the Fc region of immunoglobulin G (IgG). It plays a crucial role in immune regulation by mediating various cellular responses, including phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and the clearance of immune complexes. FCGR2A is part of a larger family of Fc gamma receptors (FcγRs), which are responsible for bridging adaptive and innate immunity by recognizing the Fc region of IgG and triggering effector cell responses. FcγR family members, including FCGR2A, are broadly expressed on the surface of various immune cells such as monocytes, macrophages, neutrophils, dendritic cells, and platelets. FCGR2A is unique among Fc receptors because of its capacity to mediate both activating and inhibitory immune responses, depending on the cellular context and signaling pathways involved.
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