Ewing Sarcoma Breakpoint Region 1 (EWSR1) Antibody
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Description
EWSR1 Antibody is a Goat Polyclonal antibody against EWSR1.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ewing Sarcoma Breakpoint Region 1 (EWSR1) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/64000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 2130, 14030, 289752 |
| NCBI Accession | NP_053733.2, NP_005234.1, NP_001156757.1, NP_001156758.1, NP_001156759.1 |
| Background | Antibody anti-EWSR1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
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Ewing Sarcoma Breakpoint Region 1 (EWSR1) Antibody
EWSR1 Antibody is a Rabbit Polyclonal antibody against EWSR1. This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
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