Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3 Phospho-Thr981 (EIF2AK3 pT981) Antibody
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Description
EIF2AK3 (pT981) Antibody is a Rabbit Polyclonal against EIF2AK3 (pT981).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3 Phospho-Thr981 (EIF2AK3 pT981) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Data | Modification: Phosphorylation // Target Modification: Thr981 |
| Recommended Dilution | ELISA: 1/40000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NZJ5 |
| Gene ID | 9451 |
| Background | Antibody anti-EIF2AK3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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EIF2AK3 antibody
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2(eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response(UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response(UPR)-induced G1 growth arrest due to the loss of cyclin-D1(CCND1). Involved in control of mitochondrial morphology and function.
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