Estrogen Receptor Beta (ESR2) Antibody (HRP)
169€ (20 µg)
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Name
Estrogen Receptor Beta (ESR2) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx108229
Tested Applications
ELISA
Description
Estrogen Receptor 2 Antibody (HRP) is a Rabbit Polyclonal antibody against Estrogen Receptor 2 conjugated to HRP.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Estrogen Receptor Beta (ESR2) Immunogen: Recombinant human Estrogen receptor beta protein (2-530AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92731 |
| Gene ID | 2100 |
| NCBI Accession | NP_001035365.1, NM_001040275.1 |
| OMIM | 601663 |
| Alias | Erb,ESRB,ODG8,ESTRB,NR3A2,ER-BETA,ESR-BETA,Estrogen receptor beta,Nuclear receptor subfamily 3 group A member 2 |
| Background | Antibody anti-ESR2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Estrogen receptor 2 (ESR2), also known as ERβ, is a closely related nuclear receptor that also mediates the effects of estrogen but has distinct roles compared to ESR1 ESR2 is expressed in a wide range of tissues, including the ovaries, prostate, brain, and cardiovascular system, where it regulates gene expression related to reproductive health, neuroprotection, and cardiovascular function ESR2 has a unique role in modulating the balance of estrogenic signaling, often acting to counterbalance the effects of ESR1 in certain tissues, such as the breast and prostate In the brain, ESR2 plays a protective role in neuronal function and is involved in processes like cognition, neurogenesis, and synaptic plasticity In addition to its neuroprotective functions, ESR2 is important for cardiovascular health, where it helps regulate vascular tone and reduce inflammation Dysregulation of ESR2 signaling is implicated in conditions such as cardiovascular disease, prostate cancer, and neurodegenerative diseases Its distinct functions make ESR2 an important target for therapeutic strategies aimed at treating estrogen-related diseases, with potential benefits in managing conditions like cancer, neurodegeneration, and cardiovascular disorders
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