Estrogen Receptor Beta (ESR2) Antibody
357.5€ (100 µg)
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Name
Estrogen Receptor Beta (ESR2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx038393
Tested Applications
ELISA, WB
Description
Rabbit Polyclonal against the ESR2 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Estrogen Receptor Beta (ESR2) Immunogen: A peptide corresponding to the N-terminal region of human ESR2 protein. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 50 kDa |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_001437 |
| Alias | Erb,ESRB,ODG8,ESTRB,NR3A2,ER-BETA,ESR-BETA,Estrogen receptor beta,Nuclear receptor subfamily 3 group A member 2 |
| Background | Antibody anti-ESR2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Estrogen receptor 2 (ESR2), also known as ERβ, is a closely related nuclear receptor that also mediates the effects of estrogen but has distinct roles compared to ESR1 ESR2 is expressed in a wide range of tissues, including the ovaries, prostate, brain, and cardiovascular system, where it regulates gene expression related to reproductive health, neuroprotection, and cardiovascular function ESR2 has a unique role in modulating the balance of estrogenic signaling, often acting to counterbalance the effects of ESR1 in certain tissues, such as the breast and prostate In the brain, ESR2 plays a protective role in neuronal function and is involved in processes like cognition, neurogenesis, and synaptic plasticity In addition to its neuroprotective functions, ESR2 is important for cardiovascular health, where it helps regulate vascular tone and reduce inflammation Dysregulation of ESR2 signaling is implicated in conditions such as cardiovascular disease, prostate cancer, and neurodegenerative diseases Its distinct functions make ESR2 an important target for therapeutic strategies aimed at treating estrogen-related diseases, with potential benefits in managing conditions like cancer, neurodegeneration, and cardiovascular disorders
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