Estrogen Receptor alpha (Phospho-Tyr537) Antibody
52€ (10 µg)
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Name
Estrogen Receptor alpha (Phospho-Tyr537) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx012436
Tested Applications
ELISA, WB, IHC
Description
Rabbit polyclonal antibody against Estrogen Receptor alpha protein. Immunogen region is C-terminal. Specificity is as follows for the reactive species: H:Y537, M:Y541, M:Y542.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Estrogen Receptor alpha Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human ER alpha around the phosphorylation site of tyrosine 537 (P-L-YP-D-L). |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | ELISA: 1/1000, WB: 1/500 - 1/3000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P03372 |
| Alias | ER,ESR,Era; ESRA,ESTRR,NR3A1,Nuclear receptor subfamily 3 group A member 1,Estradiol receptor |
| Background | Antibody anti-ESR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Estrogen receptor 1 (ESR1), also known as ERα, is a nuclear receptor that mediates the effects of estrogen, a key hormone in regulating the female reproductive system and other physiological processes ESR1 is expressed in a variety of tissues, including the breast, uterus, brain, and bones, where it regulates gene expression related to reproductive health, bone metabolism, and brain function Upon binding to estrogen, ESR1 undergoes a conformational change, allowing it to bind to estrogen response elements (EREs) on target genes and modulate their expression This activation regulates processes such as cell proliferation, differentiation, and apoptosis, and it is essential for the normal development of the reproductive organs and the maintenance of bone density Dysregulation of ESR1 has been linked to various diseases, particularly hormone receptor-positive breast cancer, where overactivation of ESR1 signaling promotes tumor cell growth and survival ESR1 is also a therapeutic target in breast cancer, with drugs like selective estrogen receptor modulators (SERMs) used to block or modulate its activity in cancer treatment
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