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ErbB2 (pY1248) Antibody
Pida mas información
935106861
info@markelab.com
Precio
281.25€ (80 µl)
Antibody anti-ERBB2
proveedor
Abbexareference
abx031859Tested Applications
ELISA, WB, DBreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
ErbB2 is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
ErbB2 (pY1248)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, DB
purification
Purified by protein G affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ERBB2
dry ice
No
availability
Shipped within 5-10 working days.
alias
Receptor tyrosine-protein kinase erbB-2,NEU,NGL,HER2,TKR1,CD340,HER-2,VSCN2,MLN 19,MLN-19,c-ERB2,c-ERB-, HER-2/neu; p185(erbB2),Metastatic lymph node gene 19 protein,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface,p185erbB2 receptor HER2
uniprot id
NCBI accession
NP_001005862.1, NP_004439.2
note
This product is for research use only.
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