Epithelial Cell Adhesion Molecule (EPCAM) Antibody
416€ (200 µl)
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935106861
info@markelab.com
name
Epithelial Cell Adhesion Molecule (EPCAM) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430513
tested applications
P-ELISA, WB
Description
Epithelial Cell Adhesion Molecule (EPCAM) Antibody is a Goat Polyclonal antibody against Epithelial Cell Adhesion Molecule (EPCAM).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Epithelial Cell Adhesion Molecule (EPCAM) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/128000, WB: 0.03-0.10 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 4072 |
| NCBI Accession | NP_002345.2 |
| Alias | ESA,KSA,M4S1,MK-1,DIAR5,EGP-2,EGP40,KS1/4,MIC18,TROP1,TACSTD1,Ep-CAM,Adenocarcinoma-associated antigen,Cell surface glycoprotein Trop-1,Epithelial cell surface antigen |
| Background | Antibody anti-EPCAM |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
Epithelial Cell Adhesion Molecule (EPCAM) , also known as CD326 or TACSTD1 (tumor-associated calcium signal transducer 1), is a transmembrane glycoprotein prominently expressed on the surface of epithelial cells in various tissues. EpCAM plays a dual role in cellular adhesion and signaling, as well as in the regulation of cell proliferation and differentiation. Originally identified as a marker on cancer cells, EpCAM is also a vital component in normal epithelial physiology, where it participates in maintaining cell-cell adhesion and the structural integrity of epithelial layers. EpCAM has become a major focus in cancer research due to its high expression in numerous epithelial tumors, including colorectal, breast, lung, and ovarian cancers. It is frequently upregulated in cancer, where it contributes to cell proliferation, migration, and invasion, as well as tumor growth and metastasis. Its presence on circulating tumor cells has made EpCAM a promising biomarker for early cancer detection and prognosis. Beyond its role in oncogenesis, EpCAM is involved in regenerative processes in epithelial tissues, influencing stem cell behavior and tissue repair.
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