Epithelial Cell Adhesion Molecule (EPCAM) Antibody

Este producto es parte de EPCAM - epithelial cell adhesion molecule
Product Graph
416€ (200 µl)

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935106861
info@markelab.com
name
Epithelial Cell Adhesion Molecule (EPCAM) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430513
tested applications
P-ELISA, WB

Description

Epithelial Cell Adhesion Molecule (EPCAM) Antibody is a Goat Polyclonal antibody against Epithelial Cell Adhesion Molecule (EPCAM).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Epithelial Cell Adhesion Molecule (EPCAM)
Host
Goat
Reactivity
Human
Recommended Dilution
P-ELISA: 1/128000, WB: 0.03-0.10 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Size 1
200 µl
Form
Liquid
Tested Applications
P-ELISA, WB
Buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Gene ID
4072
NCBI Accession
NP_002345.2
Alias
ESA,KSA,M4S1,MK-1,DIAR5,EGP-2,EGP40,KS1/4,MIC18,TROP1,TACSTD1,Ep-CAM,Adenocarcinoma-associated antigen,Cell surface glycoprotein Trop-1,Epithelial cell surface antigen
Background
Antibody anti-EPCAM
Status
RUO
Note
Concentration: 0.5 mg/ml -

Descripción

Epithelial Cell Adhesion Molecule (EPCAM) , also known as CD326 or TACSTD1 (tumor-associated calcium signal transducer 1), is a transmembrane glycoprotein prominently expressed on the surface of epithelial cells in various tissues. EpCAM plays a dual role in cellular adhesion and signaling, as well as in the regulation of cell proliferation and differentiation. Originally identified as a marker on cancer cells, EpCAM is also a vital component in normal epithelial physiology, where it participates in maintaining cell-cell adhesion and the structural integrity of epithelial layers. EpCAM has become a major focus in cancer research due to its high expression in numerous epithelial tumors, including colorectal, breast, lung, and ovarian cancers. It is frequently upregulated in cancer, where it contributes to cell proliferation, migration, and invasion, as well as tumor growth and metastasis. Its presence on circulating tumor cells has made EpCAM a promising biomarker for early cancer detection and prognosis. Beyond its role in oncogenesis, EpCAM is involved in regenerative processes in epithelial tissues, influencing stem cell behavior and tissue repair.

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