Endoglin / CD105 (ENG) Antibody
312€ (0.1 mg)
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Name
Endoglin / CD105 (ENG) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx139411
Tested Applications
WB, FCM, IP
Description
Endoglin / CD105 (ENG) Antibody is a Mouse Monoclonal Antibody against Endoglin / CD105 (ENG).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Endoglin / CD105 (ENG) Immunogen: Recombinant Vaccinia virus containing the Human CD105 cDNA. |
| Host | Mouse |
| Reactivity | Human, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | FCM: 1-5 μg/ml. WB validated in non-reducing conditions. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Clone ID | J635 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, FCM, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P17813 |
| Gene ID | 2022 |
| OMIM | 131195 |
| Alias | END,HHT1,ORW1,CD105 |
| Background | Antibody anti-ENG |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Endoglin, encoded by the ENG gene, is a key transmembrane glycoprotein in the TGF-β (transforming growth factor-beta) receptor complex, with significant roles in vascular development and endothelial cell biology. Also known as CD105, endoglin is crucial in angiogenesis and vascular homeostasis. It is prominently expressed on the surface of endothelial cells, especially in active angiogenic areas, as well as in other cell types like smooth muscle cells and some immune cells. Endoglin regulates cellular responses to TGF-β signaling, particularly within endothelial cells, which is essential for their proliferation, migration, and survival. Mutations in the ENG gene are linked to hereditary hemorrhagic telangiectasia type 1 (HHT1), a genetic disorder characterized by abnormal blood vessel formation, causing arteriovenous malformations, frequent nosebleeds, and other bleeding-related symptoms. Endoglin also plays a prominent role in cancer biology, where it can act as a biomarker for tumor angiogenesis. Its dual role in promoting normal vascular health and contributing to disease makes it an essential molecule in vascular biology research.
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