E3 Ubiquitin-Protein Ligase UHRF1 (UHRF1) Antibody
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Description
E3 Ubiquitin-Protein Ligase UHRF1 (UHRF1) Antibody is a Rabbit polyclonal antibody for the detection of Human E3 Ubiquitin-Protein Ligase UHRF1 (UHRF1).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | E3 Ubiquitin-Protein Ligase UHRF1 (UHRF1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96T88 |
| Gene ID | 29128 |
| NCBI Accession | NP_001041666.1 |
| Background | Antibody anti-UHRF1 |
| Status | RUO |
Descripción
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UHRF1 antibody
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
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