E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2) Antibody

Product Graph
169€ (20 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx344479
tested applications
ELISA, IHC, IF/ICC

Description

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2) Antibody is a Rabbit Polyclonal antibody for the detection of Human SIAH2.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G chromatography.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O43255
Gene ID
6478
OMIM
602213
Background
Antibody anti-SIAH2
Status
RUO

Descripción

Related Products

EH12289

Human SIAH2 (E3 ubiquitin-protein ligase SIAH2) ELISA Kit

Ver Producto
FNab07858

SIAH2 antibody

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation(POU2AF1, PML, NCOR1), a cell surface receptor(DCC), an antiapoptotic protein(BAG1), and a protein involved in synaptic vesicle function in neurons(SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA.

Ver Producto
P8541

Recombinant Human SIAH2

Ver Producto