E3 Ubiquitin-Protein Ligase CBL (CBL) Cell ELISA Kit
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935106861
info@markelab.com
Precio
513.5€ (96 tests)
Elisa kits for CBL
proveedor
Abbexareference
abx595099Tested Applications
ELISAreactivity
Human, Mouse, Ratstatus
RUOclonality
Descripción
CBL Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Background
CBL is an E3 ubiquitin ligase that plays a crucial role in regulating signal transduction pathways, particularly those associated with receptor tyrosine kinases (RTKs) like the epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR). CBL mediates the ubiquitination of target proteins, leading to their degradation via the proteasome, and regulates the receptor's internalization and downregulation. This process ensures the proper termination of signaling, which is important for cellular processes such as growth, differentiation, and survival. Dysregulation of CBL activity has been implicated in various cancers, as uncontrolled signaling due to deficient ubiquitination can result in unchecked cell proliferation and survival.
Características del producto
category
ELISA Kits
immunogen target
E3 Ubiquitin-Protein Ligase CBL (CBL)
reactivity
Human, Mouse, Rat
detection method
Colorimetric
size 1
96 tests
alias
CBL, C-CBL2, FRA11B, NSLL, RNF55
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
CBL
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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