E3 ubiquitin-protein ligase BRE1A (RNF20) Antibody

Product Graph
299€ (50 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
E3 ubiquitin-protein ligase BRE1A (RNF20) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx402134
tested applications
ELISA, WB, IHC, IF/ICC

Description

E3 ubiquitin-protein ligase BRE1A (RNF20) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human RNF20.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
E3 ubiquitin-protein ligase BRE1A (RNF20)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1/500 - 1/5000, IHC: 1/50 - 1/200, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG
Expression
Recombinant
Purification
Purified by affinity chromatography.
Size 1
50 µl
Size 2
100 µl
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF/ICC
Buffer
PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q5VTR2
Gene ID
56254
OMIM
607699
Background
Antibody anti-RNF20
Status
RUO

Descripción

Related Products

FNab07349

RNF20 antibody

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B(H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation(H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.

Ver Producto
P8513

Recombinant Human RNF20

Ver Producto
abx027866

Ring Finger Protein 20 (RNF20) Antibody

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3.

Ver Producto