E3 Ubiquitin-Protein Ligase AMFR (AMFR) Antibody (Biotin)
169€ (20 µg)
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Name
E3 Ubiquitin-Protein Ligase AMFR (AMFR) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx335483
Tested Applications
ELISA
Description
AMFR Antibody (Biotin) is a Rabbit Polyclonal against AMFR.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: E3 Ubiquitin-Protein Ligase AMFR (AMFR) Immunogen: Recombinant Human E3 ubiquitin-protein ligase AMFR protein (485-643AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UKV5 |
| Gene ID | 267 |
| Alias | AMFR,RNF45 |
| Background | Antibody anti-AMFR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
E3 ubiquitin-protein ligase AMFR, also known as autocrine motility factor receptor (AMFR), is an enzyme that plays a crucial role in the ubiquitin-proteasome system (UPS), which is responsible for the targeted degradation of proteins within cells. AMFR functions as an E3 ubiquitin ligase, which means it catalyzes the transfer of ubiquitin molecules from E2 ubiquitin-conjugating enzymes to target proteins, marking them for degradation by the proteasome. This process, known as ubiquitination, is essential for regulating various cellular processes, including protein turnover, signal transduction, and the maintenance of protein homeostasis. AMFR has been implicated in other cellular functions: Regulation of protein trafficking: AMFR is involved in the quality control of membrane proteins, particularly those destined for degradation in the endoplasmic reticulum-associated degradation (ERAD) pathway. It helps target misfolded or unassembled membrane proteins for ubiquitination and subsequent degradation by the proteasome. Regulation of cellular signaling: AMFR has been shown to interact with and regulate various signaling molecules and pathways, including the epidermal growth factor receptor (EGFR) signaling pathway
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