Double-Stranded RNA-Specific Adenosine Deaminase (ADAR) Antibody
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Description
Double-Stranded RNA-Specific Adenosine Deaminase (ADAR) Antibody is a Rabbit Polyclonal against Double-Stranded RNA-Specific Adenosine Deaminase (ADAR).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Double-Stranded RNA-Specific Adenosine Deaminase (ADAR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/3000 - 1/10000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P55265 |
| Gene ID | 103 |
| Background | Antibody anti-ADAR |
| Status | RUO |
Descripción
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ADAR1 is also named as ADAR1, DSRAD, G1P1, IFI4. It convert selected adenosine residues into inosine in substrate RNAs containing a relatively short dsRNA region(PMID:15556947). The human ADAR1 gene specifies two size forms of RNA-specific adenosine deaminase, an interferon(IFN) inducible ?150 kDa protein and a constitutively expressed N-terminally truncated ?110 kDa protein, encoded by transcripts with alternative exon 1 structures that initiate from different promoters(PMID:11111054). It has 5 isoforms produced by alternative promoter usage and alternative splicing. Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria(DSH).ADAR1 can form respective homodimers, and this association is essential for its enzymatic activities(PMID:17428802).
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