Dopamine Receptor D5 (DRD5) Antibody (Biotin)

Este producto es parte de DRD - Dopamine Receptor D
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169€ (20 µg)

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935106861
info@markelab.com
name
Dopamine Receptor D5 (DRD5) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx303664
tested applications
ELISA

Description

DRD5 Antibody (Biotin) is a Rabbit Polyclonal against DRD5 conjugated to Biotin.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Dopamine Receptor D5 (DRD5)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Biotin
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P21918
Gene ID
1816
OMIM
126453
Alias
DRD5,DRD1B,DRD1L2,D(1B) dopamine receptor,dopamine receptor 5,Gpcr1,DBDR
Background
Antibody anti-DRD5
Status
RUO

Descripción

DRD5 is a G protein-coupled receptor of the D1-like dopamine receptor family that couples to Gs proteins, leading to activation of adenylate cyclase and an increase in cyclic AMP (cAMP) levels. DRD5 is highly expressed in limbic brain regions, including the hippocampus, hypothalamus, and cerebral cortex, where it modulates cognition, memory, and emotional behavior. DRD5 has a higher affinity for dopamine compared to DRD1, allowing it to regulate synaptic transmission and plasticity more effectively. It plays a key role in learning, working memory, and behavioral flexibility, with its dysfunction linked to schizophrenia, cognitive deficits, and neurological disorders. DRD5 is also involved in regulating motor function and reward pathways, contributing to the dopaminergic control of behavior. In peripheral tissues, DRD5 is expressed in renal, cardiovascular, and immune systems, where it regulates sodium balance, blood pressure, and immune cell activity. Dysregulation of DRD5 signaling has been associated with hypertension and autoimmune diseases. DRD5 is a potential therapeutic target for neuropsychiatric disorders, cognitive impairment, and cardiovascular dysfunction, given its role in dopamine-mediated signaling and cellular homeostasis.

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