Dog Vascular Endothelial Growth Factor B (VEGFB) Protein

Background

VEGFB is a member of the VEGF family that primarily regulates vascular growth and energy metabolism VEGFB binds to VEGFR-1 and Neuropilin-1 (NRP1) to control endothelial cell survival without significantly promoting angiogenesis VEGFB is involved in the transport of fatty acids across endothelial cells into tissues like cardiac muscle and skeletal muscle, where it supports energy homeostasis It is critical for maintaining the health of tissues with high metabolic demand, such as the heart and brain Dysregulation of VEGFB has been linked to metabolic disorders, cardiac hypertrophy, and atherosclerosis Elevated VEGFB expression can protect tissues under ischemic conditions by preserving vascular integrity and promoting fatty acid uptake, making it a potential target for therapeutic interventions in cardiovascular diseases and metabolic syndromes