Dog Transforming Growth Factor Beta 1 (TGFB1) ELISA Kit

Este producto es parte de TGFB1 - Transforming Growth Factor Beta 1
Dog Transforming Growth Factor Beta 1 (TGFB1) ELISA Kit
715€ (96 tests)

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Name
Dog Transforming Growth Factor Beta 1 (TGFB1) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx150291
Tested Applications
ELISA

Description

Dog Transforming Growth Factor Beta 1 (TGFB1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Dog Transforming Growth Factor beta 1 (TGFb1) concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Transforming Growth Factor Beta 1 (TGFb1)

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Transforming Growth Factor Beta 1 (TGFB1)
Reactivity
Dog
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
15.6 pg/ml - 1000 pg/ml
Sensitivity
< 5.7 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Availability
Shipped within 5-7 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
CED,DPD1,IBDIMDE LAP,TGF-beta1,TGFB,TGFbeta
Background
Elisa Kits for: TGFB1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

TGFB1 is a multifunctional cytokine that belongs to the transforming growth factor beta (TGF-β) family, which regulates cell proliferation, differentiation, apoptosis, and immune responses. TGFB1 is secreted as a latent complex that is activated in response to tissue injury, hypoxia, or cellular stress, enabling it to bind to its receptors and initiate downstream SMAD-dependent and non-SMAD signaling pathways. TGFB1 is a critical regulator of tissue homeostasis, embryonic development, and immune tolerance, where it suppresses inflammatory responses and promotes regulatory T cell (Treg) differentiation. In wound healing, TGFB1 induces extracellular matrix production and fibroblast activation, facilitating tissue repair and fibrosis. However, dysregulated TGFB1 signaling contributes to cancer progression by promoting epithelial-mesenchymal transition (EMT), immune evasion, and metastasis. It also drives fibrosis in chronic diseases, including pulmonary fibrosis and liver cirrhosis. Knockout studies reveal severe developmental defects, immune dysregulation, and impaired tissue repair, underscoring TGFB1's essential roles in cellular communication, immune modulation, and tissue remodeling.

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