Dog Suppressor of cytokine signaling 3 (SOCS3) ELISA Kit
715€ (96 tests)
715€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Dog Suppressor of cytokine signaling 3 (SOCS3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx518156
tested applications
ELISA
Descripción del producto
Dog Suppressor of cytokine signaling 3 (SOCS3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Dog Suppressor of cytokine signaling 3 concentrations in serum, plasma and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | CIS3,SSI3,ATOD4,Cish3,SSI-3,SOCS-3 |
| Assay Data | Quantitative |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Background | Elisa kits for SOCS3 |
| Category | ELISA Kits |
| Detection Method | Colorimetric |
| Dry Ice | No |
| Form | Lyophilized |
| Immunogen Target | Suppressor of cytokine signaling 3 (SOCS3) |
| Name | Dog Suppressor of cytokine signaling 3 (SOCS3) ELISA Kit |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
| Price | 715 |
| Provider | Abbexa |
| Reactivity | Dog |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx518156 |
| Sample Type | Serum, plasma and other biological fluids. |
| Size 1 | 96 tests |
| Status | RUO |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Tested Applications | ELISA |
| UniProt ID | Q68AM8 |
Descripcion del producto en español
Background en español
SOCS3 is a key negative regulator of cytokine signaling that inhibits JAK/STAT signaling pathways by binding to cytokine receptors, such as the IL-6 and leptin receptors, and targeting them for proteasomal degradation. It directly suppresses JAK kinase activity, preventing STAT phosphorylation and downstream signaling, which controls processes like inflammation, immune cell activation, and energy homeostasis. SOCS3 is highly expressed in immune cells, adipose tissues, and liver, where it modulates cytokine responses, insulin sensitivity, and metabolic regulation. It is critical for limiting excessive inflammation during infections and preventing chronic inflammatory diseases. Dysregulation of SOCS3 is implicated in autoimmune diseases, metabolic disorders like obesity and insulin resistance, and cancer, where it affects cytokine balance and cellular proliferation. Knockout studies reveal embryonic lethality, hyperactivated cytokine signaling, and increased susceptibility to inflammatory and metabolic diseases, underscoring its pivotal role in immune regulation and cytokine signaling control.
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