Docking Protein 5 (DOK5) Antibody
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935106861
info@markelab.com
Precio
387.5€ (200 µl)
Antibody anti-DOK5
proveedor
Abbexareference
abx432205Tested Applications
P-ELISA, WB, IHCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
DOK5 Antibody is a Goat Polyclonal antibody against DOK5.
Background
DOK5 is a member of the DOK family, functioning as an adaptor protein in signaling pathways downstream of RET and insulin receptors. It is expressed in skeletal muscle, heart, and nervous tissue, where it regulates processes like cell survival, differentiation, and metabolic signaling. DOK5 enhances insulin signaling by activating the MAPK/ERK pathway but does not influence the PI3K/Akt pathway. It is critical for neurite outgrowth and neuronal development, particularly in response to neurotrophic factors. Dysregulation of DOK5 contributes to insulin resistance and is implicated in neurological disorders, where it affects neuronal survival and axonal guidance.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Docking Protein 5 (DOK5)
host
Goat
conjugation
Unconjugated
form
Liquid
tested applications
P-ELISA, WB, IHC
purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
size 1
200 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
DOK5
dry ice
No
availability
Shipped within 1-3 working days.
alias
Downstream of tyrosine kinase 5,C20orf180,IRS-6,IRS6,Insulin receptor substrate 6
NCBI accession
NP_060901.2
note
This product is for research use only.
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