Docking protein 2 Phospho-Tyr299 (DOK2 pY299) Antibody
429€ (100 µl)
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Name
Docking protein 2 Phospho-Tyr299 (DOK2 pY299) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx332888
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
DOK2 (pY299) Antibody is a Rabbit Polyclonal against DOK2 (pY299).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Docking protein 2 Phospho-Tyr299 (DOK2 pY299) Immunogen: Peptide sequence around phosphorylation site of tyrosine 299 (G-E-Y (p)-A-V) derived from Human p56Dok-2. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/1000, IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60496 |
| Gene ID | 9046 |
| Alias | Downstream of tyrosine kinase 2,p56DOK,p56dok-2 |
| Background | Antibody anti-DOK2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Docking protein 2 (DOK2) is another member of the DOK family, predominantly expressed in hematopoietic cells. Like DOK1, DOK2 functions as a negative regulator of tyrosine kinase-mediated signaling pathways. It is essential for modulating immune cell activation, particularly in T cells, B cells, and macrophages. DOK2 interacts with various signaling proteins, such as SH2-containing phosphatase 2 (SHP2) and Ras-GAP, to dampen downstream signaling cascades. This regulation is vital for maintaining immune homeostasis and preventing overactivation that could lead to autoimmunity. DOK2 has also been identified as a tumor suppressor, with its inactivation or downregulation contributing to the pathogenesis of leukemias and other cancers. Its roles in both immune regulation and oncogenesis make it a key target for therapeutic research.
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