935106861
info@markelab.com
Precio
187.5€ (50 µg)
DOK2 Antibody is a Rabbit Polyclonal against DOK2.
Docking protein 2 (DOK2) is another member of the DOK family, predominantly expressed in hematopoietic cells. Like DOK1, DOK2 functions as a negative regulator of tyrosine kinase-mediated signaling pathways. It is essential for modulating immune cell activation, particularly in T cells, B cells, and macrophages. DOK2 interacts with various signaling proteins, such as SH2-containing phosphatase 2 (SHP2) and Ras-GAP, to dampen downstream signaling cascades. This regulation is vital for maintaining immune homeostasis and preventing overactivation that could lead to autoimmunity. DOK2 has also been identified as a tumor suppressor, with its inactivation or downregulation contributing to the pathogenesis of leukemias and other cancers. Its roles in both immune regulation and oncogenesis make it a key target for therapeutic research.
Primary Antibodies
Polyclonal
Human, Mouse
Docking protein 2 (DOK2)
Rabbit
Unconjugated
Liquid
ELISA, WB, IHC, IF/ICC
Purified by affinity chromatography.
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
50 µg
100 µg
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
DOK2
No
Shipped within 5-10 working days.
Downstream of tyrosine kinase 2,p56DOK,p56dok-2
This product is for research use only.
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly o...
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