DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody
169€ (20 µl)
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935106861
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name
DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx321453
tested applications
ELISA, WB, IHC
Description
ALKBH2 Antibody is a Rabbit Polyclonal against ALKBH2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DNA Oxidative Demethylase ALKBH2 (ALKBH2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/200 - 1/1000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6NS38 |
| Gene ID | 121642 |
| NCBI Accession | NP_001001655.1, NM_001001655.2 |
| OMIM | 610602 |
| Alias | ALKBH2,ABH2 |
| Background | Antibody anti-ALKBH2 |
| Status | RUO |
Descripción
ALKBH2 is a key DNA repair enzyme that catalyzes the direct reversal of methylated lesions, particularly N1-methyladenine (m1A) and N3-methylcytosine (m3C), in double-stranded DNA. It is part of the alpha-ketoglutarate (α-KG)- and Fe(II)-dependent dioxygenase family, where it utilizes α-KG and molecular oxygen to demethylate damaged bases. ALKBH2 is essential for maintaining genomic integrity, as it repairs alkylation damage caused by environmental mutagens, chemotherapeutic agents, and endogenous metabolism. It operates in coordination with other DNA repair pathways to prevent mutations and DNA strand breaks. ALKBH2 is particularly active during DNA replication and cell division, ensuring faithful genome transmission. Mutations or dysregulation of ALKBH2 are associated with increased susceptibility to cancer and reduced cellular survival under genotoxic stress. Its function makes it a promising therapeutic target for enhancing the efficacy of alkylating agents in cancer treatment.
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