Disrupted In Schizophrenia 1 (DISC1) Antibody
286€ (100 µl)
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Name
Disrupted In Schizophrenia 1 (DISC1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx102996
Tested Applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Disrupted In Schizophrenia 1 (DISC1).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Disrupted In Schizophrenia 1 (DISC1) Immunogen: DISC1 (Ser102-Cys261) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-5 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | DISC1, C1orf136, SCZD9, disrupted in schizophrenia 1, DISC1 scaffold protein |
| Background | Antibody anti-DISC1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Disrupted in schizophrenia 1 (DISC1) is a scaffolding protein with diverse roles in neurodevelopment, synaptic function, and adult neurogenesis. Originally identified in a Scottish family with a high incidence of schizophrenia, DISC1 has since been implicated in several psychiatric disorders, including bipolar disorder and major depression. DISC1 interacts with multiple molecular partners, influencing signaling pathways involved in neuronal proliferation, migration, and axonal growth. Additionally, it regulates mitochondrial function and intracellular trafficking. Dysfunctional DISC1 has been associated with structural brain abnormalities, synaptic deficits, and altered neuronal connectivity, which are common features in neuropsychiatric disorders. The multifaceted roles of DISC1 in cellular processes and its potential as a biomarker or therapeutic target underscore its significance in neuroscience and psychiatry research.
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